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The peak plasma concentrations of tolcapone at this dose were on average 30 µg/ ml (compared to 3 and 6 µg/ ml with 100 mg tid and 200 mg tid of tolcapone respectively).
Die Spitzenkonzentration von Tolcapon im Plasma betrug bei dieser Dosis durchschnittlich 30 µg/ml (verglichen mit 3 µg/ml bzw. 6 µg/ml bei 100 mg bzw. 200 mg Tolcapon dreimal täglich).
If the dose is increased to 200 mg tid, liver enzyme monitoring should take place before increasing the dose and then be reinitiated following the same sequence of frequencies as above (See 4.4 and 4.8).
Falls die Dosis auf 200 mg dreimal täglich erhöht wird, muss die Kontrolle der Leberenzyme vor der Dosiserhöhung und dann entsprechend der oben angegebenen Intervallfolge stattfinden (siehe 4.4 und 4.8).
A reduction in the AUC of MPA of approximately 40 % is associated with the co-administration of cholestyramine ( 4 g TID ) , indicating that these is a significant amount of enterohepatic recirculation.
Die AUC von MPA geht um ca. 40 % zurück , wenn Mycophenolatmofetil gleichzeitig mit Cholestyramin ( 4 g , dreimal täglich ) verabreicht wird , was auf einen ausgeprägten enterohepatischen Kreislauf hinweist .

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